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GIT Simulation Environment (Muhammad Barkaat Hussain, 11 March 2015)

A well written article emphasizing the importance of combination of beneficial gut flora for therapeutic application in gut disorder, tested under GIT simulation enviroment. This reseach opens new avenues for future research, particularly if nutural product like honey could be evaluated against gut pathogen because honey contain multiple beneficial gut flora, originated from bee stoch. Moreover honey contain prebiotics which stimulate the growth of indiginous gut flora. Authors deserve congratulations and appreciations for such a nice research. May Allah Almighty grant them more energy for future work. Best Regards Muhammad Barkaat Hussain read full comment

Comment on: Mathipa et al. Gut Pathogens, 7:5

Acknowledgements (Stefan Herbel, 02 October 2013)

Stefan Herbel was supported by the German Research Foundation (grant no. SFB852/1), and Sebastian Guenther was supported by ZIM fond (Zentrales Innovationsprogramm Mittelstand) grant no. KF2267401MD9. read full comment

Comment on: Herbel et al. Gut Pathogens, 5:27

Addendum to Acknowledgements (Astrid Bethe, 11 May 2012)

This work was supported by the BMBF-network "FBI-Zoo" (Food-Borne Zoonotic Infections of Humans, grant no. 01KI1012A) read full comment

Comment on: Wieler et al. Gut Pathogens, 3:17

I agree (Ramy Karam Aziz, 28 December 2009)

Dear Xandra,
thanks for your comment
"However, describing bacteria as having a pathogenic lifestyle is in itself, anthropomorphic."
I certainly agree. There are many anthropocentric/anthropomorphic terms in the article, including the term 'microbes' itself. I just had to use some conventional terms to avoid being fully (mis-)understood!

"Many bacteria considered pathogens are not generally harmful to humans, but are in the wrong place or in the right place at the wrong time."
I agree too. I referred to this particular point in this commentary: A hundred-year-old insight into the gut microbiome!

Thank you again for the critical reading

RKA read full comment

Comment on: Aziz Gut Pathogens, 1:16

Correction (Ramy Karam Aziz, 28 December 2009)

I have been emailed by a reader about a typographical mistake.

The end of the first paragraph of the Introduction section should read: "for years[4]" instead of "for year[4]".

Below is the original reader's email, sent on 11 Sep 2009:

Dear Dr Aziz,

Thanks very much for your paper on anthropomorphism in microbiology. It was a very enjoyable read, as well as making an important point about the universe. Congratulations!

There is a typo at the end of the first paragraph of the introduction: it reads "a landmark discovery that was resisted for year[4]." That should be years.

That is all,
Best wishes
Douglas Carnall
" read full comment

Comment on: Aziz Gut Pathogens, 1:16

What is a pathogen? (Xandra Smith, 05 September 2009)

I agree with the author that the study of microbes should be all inclusive and not focus mainly on those that interact with humans, whether in a beneficial or harmful way. However, describing bacteria as having a pathogenic lifestyle is in itself, anthropomorphic. Many bacteria considered pathogens are not generally harmful to humans, but are in the wrong place or in the right place at the wrong time. Using your example, legionellae are not normally present in human macrophages, but in protozoa i.e. they are in the wrong place. Bacterial diarrheal disease in neonates may be caused by coliforms, which are commensal to the gastrointestinal tract, but usually only become established at later time points. Due to alterations in human behaviors; e.g. formula feeding; these bacteria are in the... read full comment

Comment on: Aziz Gut Pathogens, 1:16

Thanks + Answer (Ramy Karam Aziz, 20 August 2009)

It is certainly a pleasure to see comments by a networks engineer, a science editor, and one of my undergraduate students, especially that online commenting on scientific articles is not yet as popular as commenting on blog posts. This is particularly encouraging because I was hoping that the article can reach a wide audience, not just microbiologists and ID specialists.

As an answer to Mariam's "undergraduate" question: In the cited references 21 and 23, Norman Pace* leads a campaign to use the terms Bacteria and Arachaea as two different groups, and to avoid using the term prokaryote/procaryote. His call does not go unchallenged (see for example references 22 and 24). We definitely still use a lot of scientifically... read full comment

Comment on: Aziz Gut Pathogens, 1:16

Exciting article. (Mariam Rizkallah, 17 August 2009)

When I read the article for the first time, I was shocked! The article is providing a very different perspective, at least different than what I always dreamed of as a pharmacy student, to terminate harmful bacteria by designing an effective, highly selective chemotherapeutic!

What I got from the article is that the current human-centered view for microbiology has three major drawbacks: 1) Compared to medical microbiology, environmental microbiology is way underestimated, to medical students for example 2) It's clouding the overall view regarding bacterial evolution, because we stay focused on just m.o. of medical interest apart from their relatives from non-pathogenic bacteria 3) It's not providing us with the big picture of pathogenesis.

In fact, I spent all... read full comment

Comment on: Aziz Gut Pathogens, 1:16

Countering anthropocentrism (Merry Youle, 11 August 2009)

I was delighted by this excellent (open access!) commentary expressing a much needed perspective. The ideas expressed are very pertinent to all of biology, yet are all too often dismissed as trivial. Our anthropocentrism is deep, pervasive, unquestioned. The distortions in our way of seeing the rest of the planet seem to be particularly strong when it comes to microbes (including viruses). We miss so much by seeing them only in terms of their impact on our lives or their potential usefulness to us. As Aziz points out, this myopia has led to the skewed selection of genomes for sequencing, and thus the terra incognita remaining within the Tree of Life even as we approach 1,000 sequenced microbial genomes. Fortunately, biocentrism is increasing, thanks in part to the publication of articles... read full comment

Comment on: Aziz Gut Pathogens, 1:16

Network Architect (Tarek Amr, 08 August 2009)

As you can see, I am an Engineer, and I almost know nothing about Biology and Medicine, however reading this article was really informative and it was very clear even for someone like me.

I liked the following parts the most:

"Thus, to imagine that the raison d’être of pathogenic or opportunistic bacteria is to survive by “harming” their host is simplistic, to say the least. The alternative viewpoint, which remains surprisingly uncommon in scientific literature and textbooks, is that some bacteria that had been stranded in the human body were driven to gradually evolve and adapt to such a hostile environment"

"Who attacks whom, that is the question! Indeed, the fact that we, humans, have more bacterial cells than our own cells has... read full comment

Comment on: Aziz Gut Pathogens, 1:16