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Open Access Short report

Diversified pattern of the human colorectal cancer microbiome

Jiawei Geng12, Hong Fan1, Xiaodan Tang1, Huiqin Zhai1 and Zhigang Zhang2*

Author Affiliations

1 Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Kunming, 650032, China

2 State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

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Gut Pathogens 2013, 5:2  doi:10.1186/1757-4749-5-2

Published: 7 March 2013

Abstract

Background

The aim of this study is to expand existing knowledge about the CRC-associated microbiome among Han Chinese, and to further discover the variation pattern of the human CRC microbiome across all population.

Findings

Using pyrosequencing-based molecular monitoring of bacterial 16S rRNA gene from eight tumor/normal tissue pairs of eight Chinese CRC patients, we analyzed and characterized the basic features of the CRC-associated microbiome. Firstly, we discovered an increasing diversity among tumor-associated bacterial communities. Secondly, in 50% of Chinese CRC patients, we found a significant increase of Roseburia (P = 0.017), and a concurrent decrease of both Microbacterium (P = 0.009) and Anoxybacillus (P = 0.009) in tumor tissue.

Conclusions

We discovered a novel CRC microbiome pattern in Chinese. Both the over-represented Roseburia bacteria at tumor sites and the over-represented Microbacterium and Anoxybacillus bacteria away from tumor sites were both closely related in Chinese CRC patients. Across several populations reported in this study and previously, we observed both common and distinctive patterns of human CRC microbiome’s association with a high-risk of CRC.

Keywords:
Chinese; CRC; Microbiome; Pyrosequencing