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Genome sequencing and analysis of Salmonella enterica serovar Typhi strain CR0063 representing a carrier individual during an outbreak of typhoid fever in Kelantan, Malaysia

Ramani Baddam1, Narender Kumar1, Sabiha Shaik1, Tiruvayipati Suma12, Soo Tein Ngoi23, Kwai-Lin Thong23 and Niyaz Ahmed12*

Author Affiliations

1 Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India

2 Institute of Biological sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia

3 Laboratory of Biomedical Science and Molecular Microbiology, UMBIO Research Cluster, University of Malaya, Kuala Lumpur, Malaysia

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Gut Pathogens 2012, 4:20  doi:10.1186/1757-4749-4-20

Published: 13 December 2012

Abstract

Salmonella Typhi is a human restricted pathogen with a significant number of individuals as asymptomatic carriers of the bacterium. Salmonella infection can be effectively controlled if a reliable method for identification of these carriers is developed. In this context, the availability of whole genomes of carrier strains through high- throughput sequencing and further downstream analysis by comparative genomics approaches is very promising. Herein we describe the genome sequence of a Salmonella Typhi isolate representing an asymptomatic carrier individual during a prolonged outbreak of typhoid fever in Kelantan, Malaysia. Putative genomic coordinates relevant in pathogenesis and persistence of this carrier strain are identified and discussed.