Table 1 |
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Bacterial adhesive structures and their cognate receptors |
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|
Pathogen |
Adhesin |
Receptor |
Effect on host cell |
Reference |
|
|
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|
EPEC |
BFP EspA Intimin |
Not fully elucidated Not fully elucidated Tir |
Activation of T3SS1 and formation of A/E2 lesions and changes of epithelial cell morphology |
|
|
|
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|
Salmonella sp. |
FimA FimH |
Mannosylated proteins in epithelial cells |
Activation of T3SS and transport of effector proteins necessary for invasion |
[14] |
|
|
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|
Shigella sp. |
Complex IpaB/C IpaB |
Integrin α5 β1 CD44 (natural receptor of hyaluronic acid) |
Activation of T3SS and transport of effector proteins necessary for invasion |
|
|
|
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|
Yersinia sp. |
Invasin YadA |
β1 integrins (natural receptor of fibronectin) |
Activation of T3SS and transport of effector proteins necessary for invasion and/or apoptosis |
[44] |
|
|
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|
1. T3SS: Type III Secretion System. 2. A/E lesion: attaching/effacing lesion. |
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|
Reis and Horn Gut Pathogens 2010 2:8 doi:10.1186/1757-4749-2-8 |
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