Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes

doi:10.1186/1757-4749-1-23

Gut Pathogens

Volume 1

Viewing options:

Abstract
Full text
PDF (848KB)

Associated material:

Related literature:

Articles citing this article
on Google Scholar
on PubMed Central
Other articles by authors
on Google Scholar

Van de Velde S
Carryn S
Van Bambeke F
Hill C
Tulkens PM
Sleator RD

on PubMed

Van de Velde S
Carryn S
Van Bambeke F
Hill C
Tulkens PM
Sleator RD
Related articles/pages
on Google

on Google Scholar

on PubMed

Tools:

Post to:

Short report

Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes

Sébastien Van de Velde¹ , Stéphane Carryn¹^,2 , Françoise Van Bambeke¹ , Colin Hill³ , Paul M Tulkens¹ and Roy D Sleator³^,4

¹Unité de pharmacologie cellulaire et moléculaire, Université catholique de Louvain, Bruxelles, Belgium

²Eumedica Pharmaceuticals sa, Manage, Belgium

³Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

⁴Department of Biological Sciences, Cork Institute of Technology, Rossa Avenue, Bishopstown, Cork, Ireland

author email corresponding author email

Gut Pathogens 2009, 1:23doi:10.1186/1757-4749-1-23


Published:	15 December 2009

Abstract

While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.