Short report
Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes
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* Corresponding author: Roy D Sleator roy.sleator@cit.ie
1 Unité de pharmacologie cellulaire et moléculaire, Université catholique de Louvain, Bruxelles, Belgium
2 Eumedica Pharmaceuticals sa, Manage, Belgium
3 Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
4 Department of Biological Sciences, Cork Institute of Technology, Rossa Avenue, Bishopstown, Cork, Ireland
Gut Pathogens 2009, 1:23 doi:10.1186/1757-4749-1-23
Published: 15 December 2009Abstract
While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.