Table 1 |
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|
Adhesins of extraintestinal pathogenic E. coli |
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| Adhesin |
Gene |
Receptor specificity |
Cell adherence: in vitro and in vivo infection models |
Reference |
|
|
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| Type 1 fimbriae |
fim |
Mannose oligosaccharides (Mono- and Tri-mannose) |
Human bladder epithelium, Chicken tracheal and gut explants, colonic and ileal enterocytes |
[6,14,15,98,99] |
| P fimbriae |
pap |
P-blood group antigen-specific glycosphingolipids (α-D-Galp-(1-4)-β-D-Galp) |
Human kidney, colonic and ileal enterocytes |
[31,38,99] |
| Curli |
csg |
Matrix and Plasma Proteins (Fibronectin, Laminin, Plasminogen, H-Kininogen) |
Chicken tracheal and gut explants |
[51,98,99] |
| S fimbriae |
sfa |
Neuraminic acid (Sialyl galactosides) |
Human bladder and kidney epithelium, Brain endothelium, colonic and ileal enterocytes |
[6,99,106-110] |
| F1C fimbriae |
foc |
Lactosylceramide containing glycolipids |
Buccal epithelium, Collecting ducts and distal tubules of human kidney, renal tubulus
cells |
[6,68-70,73] |
| Dr fimbriae |
dra |
Dr blood group antigen, Decay accelerating factor (DAF) |
Basement membranes of human and canine kidneys, Bowman's capsule, Bladder epithelium,
colonic and ileal enterocytes |
[75,77,99] |
| Afimbrial adhesins |
afa |
DAF |
Uroepithelial cells |
[6,83] |
| Temperature sensitive haemagglutinin |
tsh |
Haemoglobin, Fibronectin, Collagen IV |
Chicken erythrocytes |
[90,91] |
| UPEC trimeric autotransporter adhesin |
upa |
Fibronectin, Laminin |
Human bladder epithelial cells |
[93] |
| ExPEC Adhesin I |
yqi |
n.d. |
Chicken lung epithelium, Chicken fibroblasts, Canine kidney epithelial cells |
[96] |
|
|
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|
n.d.: Not determined |
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|
Antão et al. Gut Pathogens 2009 1:22 doi:10.1186/1757-4749-1-22 |
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