Commentary

Spirochaetes as intestinal pathogens: Lessons from a Brachyspira genome

David J Hampson¹ and Niyaz Ahmed²

¹  Animal Research Institute, School of Veterinary and Biomedical Science, Murdoch University, Murdoch, Western Australia 6150, Australia

²  Department of Biotechnology, Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India

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Gut Pathogens 2009, 1:10doi:10.1186/1757-4749-1-10

Published:	1 May 2009

Abstract

Anaerobic spirochaetes of the genus Brachyspira have long been known as important gut pathogens of pigs, but increasingly they are recognised as causing disease in birds and other animal species, including human beings. The genome sequence of the major swine pathogen Brachyspira hyodysenteriae was recently published, and this revealed extensive genome optimisation that leads to adaptation to the complex environment of the colon. The genome sequences of other pathogenic and non-pathogenic Brachyspira species are becoming available, and this data will help to reveal how these species have evolved and adapted to varied lifestyles in the large intestines of different species, and why some but not others can induce colitis and diarrhoea.